Title: Análisis de la activación neuronal mediante resonancia magnética funcional en pacientes disléxicos
Principal Investigator: Ph.D. Begoña García Zapirain
Participants: Osatek, Universidad de Deusto
Convocatory: Programa FIS
From an evolutionary perspective, reading and writing are very recent inventions, in contrast to language. Reading is a complex process that involves various phonological, orthographic, syntactic and semantic processes that make it possible to interpret the meaning of written information.
Developmental dyslexia is a disorder which has usually been defined as an unexpected reading difficulty which affects children and adults with no other intellectual deficiency or lack of motivation and who have sufficient access to education. Some researchers have advocated an independent etiology apart from the phonological deficit: a visual attention span deficit that may coexist with the phonological deficit in some dyslexic children.
With the aim of evaluating the causal role of ocular motility disorders in dyslexia, the Project presents a study of the brain activation and the underlying brain connectivity focused on the Visual Word Form Area and the left Arcuate Fasciculus in three groups of Spanish children: Typically Developing (TDR), Dyslexics (DXR) and Monocular Vision readers (MVR).
57 children were evaluated using psychological, intelligence and ophthalmological tests. Subsequently, fMRI during the reading of words and pseudowords and tractography were performed.
So this study uses DTI and fMRI to evaluate language related anatomical pathways and functional activations. In particular, children with dyslexia and children with impaired binocular vision due to ocular motility disorders have taken part in the testing, and then compared to a control group of normal readers, grouped according to sex and age.
The results show that Spanish dyslexic children may have a brain circuit for reading different from both children with monocular vision and controls.